Allicin attenuated hepatic ischemia/reperfusion injury in mice by regulating PPARγ-IRAK-M-TLR4 signal pathway
Weiwei Li, Rui Huang, Xia Gong, Zizuo Zhao, Lidan Zhang, Qin Zhou, Xujie Jiang, Hongtao Tie, Jingyuan Wan, Bin Wang
Abstract
This study shows that allicin has a protective effect on hepatic I/R injury by inhibiting hepatic apoptosis, inflammation and oxidative stress. It may be involved in regulating PPARγ-IRAK-M-TLR4 signal pathway and could be used as a therapeutic drug.
Topics & Concepts
AllicinReperfusion injuryLiver injuryPeroxisome proliferator-activated receptorOxidative stressPharmacologyMedicineApoptosisTumor necrosis factor alphaIschemiaEndocrinologyChemistryBiologyInternal medicineImmunologyReceptorBiochemistryGarlic and Onion StudiesPeroxisome Proliferator-Activated ReceptorsCholesterol and Lipid Metabolism