BMP2 inhibits cell proliferation by downregulating EZH2 in gastric cancer
Zilu Chen, Liyue Yuan, Xiaopeng Li, Junhui Yu, Zhengshui Xu
Abstract
BMP: bone morphogenetic protein; TGF-β: transforming growth factor-beta; EZH2: enhancer of zeste homolog 2; H3K27me3: trimethylation histone H3 lysine 27; HRECs: human retinal endothelial cells; PcG: polycomb group; PRC: polycomb repressive complexes.
Topics & Concepts
Cancer researchEZH2Bone morphogenetic proteinBone morphogenetic protein 2CancerBiologySMADCancer cellCell cycleCell growthSignal transductionEpigeneticsCell biologyGeneticsGeneIn vitroTGF-β signaling in diseasesEpigenetics and DNA MethylationRenal and related cancers