Nickel-catalysed chemoselective C-3 alkylation of indoles with alcohols through a borrowing hydrogen method
Amreen K. Bains, Ayanangshu Biswas, Debashis Adhikari
Abstract
An inexpensive, air-stable, isolable nickel catalyst is reported that can perform chemoselective C3-alkylation of indoles with a variety of alcohols following "borrowing hydrogen". A one-pot, cascade C3-alkylation starting from 2-aminophenyl ethyl alcohols, and thus obviating the need for pre-synthesized indoles, further adds to the broad scope of this method. The reaction is radical-mediated, and is significantly different from other examples, often dictated by metal-ligand bifunctionality.
Topics & Concepts
AlkylationChemistryNickelHydrogenIndole testCatalysisOrganic chemistryCombinatorial chemistryAsymmetric Hydrogenation and CatalysisMetal-Organic Frameworks: Synthesis and ApplicationsCarbon dioxide utilization in catalysis