Role of the thymus in spontaneous development of a multi-organ autoimmune disease in human immune system mice
Mohsen Khosravi‐Maharlooei, Haowei Li, Markus Hoelzl, Guiling Zhao, Amanda Ruiz, Aditya Misra, Yang Li, Nato Teteloshvili, Grace Nauman, Nichole Danzl, Xiaolan Ding, Elisha Y. Pinker, Aleksandar Obradović, Yong‐Guang Yang, Alina C. Iuga, Rémi J. Creusot, Robert Winchester, Megan Sykes
Topics & Concepts
AutoimmunityImmune systemImmunologyBiologyThymocyteAntigenAutoimmune diseaseT cellMajor histocompatibility complexTransgeneNegative selectionGenetically modified mouseImmune toleranceAntibodyGeneGeneticsGenomeT-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune Cell Function and Interaction