Hyperactive reactive oxygen species impair function of porcine Sertoli cells via suppression of surface protein ITGB1 and connexin-43
Dan-Chen Zhang, Chen Rong, Cai Yi-Hui, Jingjing Wang, Chang Yin, Kang Zou
Abstract
system, we found that hyperactive ROS caused extensive apoptosis in Sertoli cells, remarkable decrease in Cx43 expression, and failed maintenance of co-cultured spermatogonial stem cells (SSCs), indicating that ROS impaired the function of Sertoli cells and promoted loss of SSCs. This observation provides a possible mechanism for the impact of ROS on fertility of male animals.
Topics & Concepts
Sertoli cellConnexinCell biologyGap junctionSpermatogenesisReactive oxygen speciesBiologyOxidative stressBlood–testis barrierApoptosisInternal medicineEndocrinologyIntracellularBiochemistryMedicineConnexins and lens biologySperm and Testicular FunctionHeat shock proteins research