Piperidine Azasugars Bearing Lipophilic Chains: Stereoselective Synthesis and Biological Activity as Inhibitors of Glucocerebrosidase (GCase)
Francesca Clemente, Camilla Matassini, Sara Giachetti, Andrea Goti, Amelia Morrone, Macarena Martínez‐Bailén, Sara Orta, Pedro Merino, Francesca Cardona
Abstract
= 15 μM), in agreement with MD simulations that allowed us to identify the chair conformation corresponding to the best binding affinity.
Topics & Concepts
ChemistryStereoselectivityStereocenterStereochemistryAminationReductive aminationLigand (biochemistry)AlkylationCombinatorial chemistryCatalysisOrganic chemistryEnantioselective synthesisBiochemistryReceptorCarbohydrate Chemistry and SynthesisLysosomal Storage Disorders ResearchTrypanosoma species research and implications