Structural characterisation of deer sinew peptides as calcium carriers, their promotion of MC3T3-E1 cell proliferation and their effect on bone deposition in mice
Li Sun, Jinze Liu, Hongyan Pei, Meiling Shi, Weijia Chen, Ying Zong, Yan Zhao, Jianming Li, Rui Du, Zhongmei He
Abstract
studies revealed that deer sinew peptide-calcium chelate (DSPs-Ca) promoted the proliferation of MC3T3-E1 cells without toxic side effects and increased the alkaline phosphatase activity. The DSPs-Ca group improved the bone microstructure induced by low calcium, as well as up-regulated the expression of genes responsible for calcium uptake in the kidneys, as evidenced by serum markers, bone sections, bone parameters, and gene expression analyses in low-calcium-fed mice. From the above, it can be concluded that DSPs-Ca is expected to be a calcium supplement food for promoting bone health.
Topics & Concepts
CalciumCell growthOsteoblastChemistryCell biologyEndocrinologyInternal medicineBiochemistryMedicineBiologyIn vitroProtein Hydrolysis and Bioactive PeptidesAntimicrobial Peptides and ActivitiesSilk-based biomaterials and applications