Immune imprinting as a barrier to effective COVID-19 vaccines
Julia N. Faraone, Shan‐Lu Liu
Abstract
Wang and colleagues show that immune imprinting impairs neutralizing antibody titers for bivalent mRNA vaccination against SARS-CoV-2 Omicron subvariants. Imprinting from three doses of monovalent vaccine can be alleviated by BA.5 or BQ-lineage breakthrough infection but not by a bivalent booster. 1
Topics & Concepts
Bivalent (engine)Imprinting (psychology)Immune systemVirologyBiologyAntigenAntibodyTiterVaccinationVirusImmunologyGeneChemistryGeneticsMetalOrganic chemistrySARS-CoV-2 and COVID-19 ResearchBlood groups and transfusionImmunodeficiency and Autoimmune Disorders