Influenza Virus Neuraminidase Engages CD83 and Promotes Pulmonary Injury
Ning Ma, Xingjie Li, Hongyu Jiang, Yulong Dai, Guofeng Xu, Zongde Zhang
Abstract
The massive release of circulating mediators of inflammation is responsible for lung injury during influenza A virus infection. This phenomenon is referred to as the "cytokine storm." However, the mechanism by which influenza induces the cytokine storm is not fully understood. In this study, we have shown that neuraminidase unmasked CD83 protein in the lung and contributed to high cytokine levels. Anti-CD83 treatment could diminish immune damage to lung tissue. The NA-CD83 axis may represent a target for an interruption of influenza-induced lung damage.
Topics & Concepts
BiologyCytokine stormNeuraminidaseCytokineVirusInfluenza A virusVirologyInflammationImmunologyLungMechanism (biology)Coronavirus disease 2019 (COVID-19)MedicinePathologyInternal medicineDiseaseInfectious disease (medical specialty)EpistemologyPhilosophyInfluenza Virus Research StudiesImmune Response and Inflammationinterferon and immune responses