Kinetic Resolution of [2.2]Paracyclophane-Derived Cyclic <i>N</i>-Sulfonylimines via Palladium-Catalyzed Addition of Arylboronic Acids
Yang Zhao, Xiaoqing Wang, Yanjiang Yu, Yong‐Gui Zhou
Abstract
A facile method for kinetic resolution of [2.2]paracyclophane-derived cyclic N-sulfonylimines based on palladium-catalyzed addition of arylboronic acids was developed, giving two kinds of planar chiral [2.2]paracyclophane derivatives in excellent diastereoselectivities and up to 99% of enantioselectivities with high selectivity factors (s up to 128).
Topics & Concepts
ChemistryPalladiumKinetic resolutionCatalysisSelectivityCombinatorial chemistryPlanarOrganic chemistryEnantioselective synthesisComputer scienceComputer graphics (images)Synthesis and Properties of Aromatic CompoundsSurface Chemistry and CatalysisAsymmetric Hydrogenation and Catalysis