Exploring the dual effect of novel 1,4-diarylpyranopyrazoles as antiviral and anti-inflammatory for the management of SARS-CoV-2 and associated inflammatory symptoms
Azizah M. Malebari, Hany E. A. Ahmed, Saleh Ihmaid, Abdelsattar M. Omar, Yosra A. Muhammad, Sultan S. Althagfan, Naif Aljuhani, Abdel‐Aziz A. A. El‐Sayed, Ahmed H. Halawa, Heba M. Eltahir, Safaa A. Turkistani, Mohammed Almaghrabi, Ahmed K. B. Aljohani, Ahmed M. El‐Agrody, Hamada S. Abulkhair
Topics & Concepts
Vero cellChemistryIn vitroIn vivoDocking (animal)CytotoxicityProteaseLopinavirAnti-inflammatoryIC50Cytokine stormPharmacologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)VirusEnzymeCoronavirus disease 2019 (COVID-19)BiochemistryVirologyInfectious disease (medical specialty)BiologyMedicineViral loadDiseaseBiotechnologyAntiretroviral therapyNursingPathologySynthesis and biological activityComputational Drug Discovery MethodsResearch on Leishmaniasis Studies