Glucose influences endometrial receptivity to embryo implantation through O-GlcNAcylation-mediated regulation of the cytoskeleton
Peter T Ruane, I. Paterson, Beth Reeves, Daman J. Adlam, Stéphane Berneau, Lewis Renshall, Jan J. Brosens, Susan J. Kimber, Daniel R. Brison, John Aplin, Melissa Westwood
Abstract
Understanding how glucose regulates endometrial function will support preconception guidance and/or the development of targeted interventions for individuals living with diabetes wishing to embark on pregnancy. We found that glucose can influence endometrial epithelial cell receptivity to embryo implantation by regulating posttranslational modification of proteins involved in the maintenance of cell polarity. Impaired or inappropriate endometrial receptivity could contribute to fertility and/or early pregnancy complications caused by poor glucose control.
Topics & Concepts
EmbryoCell biologyCytoskeletonReceptivityBiologyAndrologyEndocrinologyCellGeneticsMedicineReproductive System and PregnancySignaling Pathways in DiseaseReproductive Biology and Fertility