Immunogenic tumor cell death promotes dendritic cell migration and inhibits tumor growth via enhanced T cell immunity
Taiki Moriya, Kurumi Kitagawa, Yuuki Hayakawa, Hiroaki Hemmi, Tsuneyasu Kaisho, Satoshi Ueha, Ryoyo Ikebuchi, Ippei Yasuda, Yasutaka Nakanishi, Tetsuya Honda, Koji Matsushima, Kenji Kabashima, Mizuki Ueda, Yutaka Kusumoto, Tatyana Chtanova, Michio Tomura
Abstract
DC-dependent manner. However, combining tumor cell death induction with lipopolysaccharide treatment stimulated Ti-DC maturation and emigration to dLNs but did not improve tumor immunity. Thus, immunogenic tumor cell death enhances tumor immunity by increasing Ti-DC migration to dLNs where they promote anti-tumor T cell responses and tumor growth inhibition.
Topics & Concepts
Cell biologyImmunityChemistryDendritic cellCellImmunogenic cell deathCell growthProgrammed cell deathCell mediated immunityBiologyImmune systemImmunologyApoptosisBiochemistryImmune Cell Function and InteractionImmunotherapy and Immune ResponsesPhagocytosis and Immune Regulation