Apicoplast biogenesis mediated by ATG8 requires the ATG12–ATG5-ATG16L and SNAP29 complexes in <i>Toxoplasma gondii</i>
Jiawen Fu, Lin Zhao, Yu Pang, Heming Chen, Hayashi Yamamoto, Yuntong Chen, Zhaoran Li, Noboru Mizushima, Honglin Jia
Abstract
: AID: auxin-inducible degron; CCD: coiled-coil domain; HFF: human foreskin fibroblast; IAA: indole-3-acetic acid; LAP: LC3-associated phagocytosis; NAA: 1-naphthaleneacetic acid; PtdIns3P: phosphatidylinositol-3-phosphate; SNARE: soluble N-ethylmaleimide sensitive factor attachment protein receptor; UDS: ubiquitin-interacting motif-docking site; UIM: ubiquitin-interacting motif.
Topics & Concepts
ApicoplastATG8BiologyATG5ATG12BiogenesisToxoplasma gondiiAutophagyApicomplexaCell biologyLipid-anchored proteinVirologyOrganelle biogenesisGeneticsImmunologyGenePlasmodium falciparumAntibodyApoptosisMalariaToxoplasma gondii Research StudiesAutophagy in Disease and TherapyHeme Oxygenase-1 and Carbon Monoxide