The relationships between age, sex, and cerebrovascular reactivity to hypercapnia using traditional and kinetic-based analyses in healthy adults
Jodie L. Koep, Bert Bond, Alan R. Barker, Stefanie L. Ruediger, Faith K. Pizzey, Jeff S. Coombes, Tom G. Bailey
Abstract
We observed similar MCA CVR and ICA reactivity in males and females. However, kinetic responses of the MCA to hypercapnia suggest that advancing age slows down the rate at which MCA velocity increases in response to hypercapnia. These data indicate distinct regulatory differences, and an impaired vasomotor control of the cerebrovasculature with advancing age, not detected by traditional methods.
Topics & Concepts
Middle cerebral arteryHypercapniaMedicineInternal carotid arteryTranscranial DopplerCardiologyModerationInternal medicineReactivity (psychology)PsychologyIschemiaRespiratory systemPathologyAlternative medicineSocial psychologyCerebrovascular and Carotid Artery DiseasesTraumatic Brain Injury and Neurovascular DisturbancesCardiovascular Health and Disease Prevention