Multifaceted mechanisms mediating cystine starvation-induced ferroptosis
Zhennan Shi, Nathchar Naowarojna, Zijian Pan, Yilong Zou
Abstract
The cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis is the most frequently targeted pathway to trigger the ferroptosis cascade and suppress tumor growth. Two recent studies present additional mechanisms underlying cystine starvation-induced ferroptosis apart from impaired GSH synthesis.
Topics & Concepts
GlutathioneCystineGPX4StarvationCell biologyChemistryGPX1Glutathione peroxidaseBiologyBiochemistryCysteineEnzymeEndocrinologyFerroptosis and cancer prognosisEpigenetics and DNA MethylationBladder and Urothelial Cancer Treatments