Discovery of <i>N</i>-β-<scp>l</scp>-Fucosyl Amides as High-Affinity Ligands for the <i>Pseudomonas aeruginosa</i> Lectin LecB
Patrycja Mała, Eike Siebs, Joscha Meiers, Katharina Rox, Annabelle Varrot, Anne Imberty, Alexander Titz
Abstract
-fucosyl amides in complex with LecB revealed the interactions responsible for the high affinity of the β-anomer at atomic level. Further, the molecules showed good stability in murine and human blood plasma and hepatic metabolism, providing a basis for future development into antibacterial drugs.
Topics & Concepts
ChemistryPseudomonas aeruginosaLectinAntimicrobialBiofilmBiochemistrySmall moleculeAnomerBacteriaStereochemistryMicrobiologyOrganic chemistryGeneticsBiologyAntimicrobial Peptides and ActivitiesBiochemical and Structural CharacterizationBacteriophages and microbial interactions