Replacing the refinement for skin sensitization testing: Considerations to the implementation of adverse outcome pathway (AOP)-based defined approaches (DA) in OECD guidelines
Susanne N. Kolle, Robert Landsiedel, Andreas Natsch
Topics & Concepts
Adverse Outcome PathwayGuidelineLocal lymph node assaySkin sensitizationAnimal testingReplicateRisk analysis (engineering)Computer scienceOutcome (game theory)Good laboratory practiceSensitizationManagement scienceMedicineComputational biologyPathologyEngineeringBiologyMathematical economicsStatisticsEcologyMathematicsImmunologyQuality assuranceExternal quality assessmentContact Dermatitis and AllergiesAnimal testing and alternativesImmunotoxicology and immune responses