Evaluation of Hepatic Uptake of OATP1B Substrates by Short Term-Cultured Plated Human Hepatocytes: Comparison With Isolated Suspended Hepatocytes
Takashi Yoshikado, Wooin Lee, Kota Toshimoto, Kiyoe Morita, Aya Kiriake, Xiaoyan Chu, Nora Lee, Emi Kimoto, Manthena V. S. Varma, Ryota Kikuchi, Renato J. Scialis, Hong Shen, Naoki Ishiguro, Ralf Lotz, Albert P. Li, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama
Topics & Concepts
HepatocyteEffluxChemistryCerivastatinPitavastatinPravastatinTransporterCell cultureBiochemistryChromatographyBiologyStatinCholesterolIn vitroGeneGeneticsDrug Transport and Resistance MechanismsLiver Disease Diagnosis and TreatmentDrug-Induced Hepatotoxicity and Protection