Synthesis of maleimide fused benzocarbazoles and imidazo[1,2-<i>a</i>]pyridines <i>via</i> rhodium(<scp>iii</scp>)-catalyzed [4 + 2] oxidative cycloaddition
Bin Li, Chenhao Guo, Nana Shen, Xinying Zhang, Xuesen Fan
Abstract
In this paper, an efficient and sustainable synthesis of maleimide-fused benzocarbazoles/imidazo[1,2-<italic>a</italic>]pyridines from the reaction of 2-arylindoles/2-arylimidazo[1,2-<italic>a</italic>]pyridines with maleimides through oxidative [4 + 2] annulation is presented.
Topics & Concepts
MaleimideChemistryAnnulationRhodiumCycloadditionCatalysisOxidative phosphorylationMedicinal chemistryOrganic chemistryCombinatorial chemistryBiochemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsBioactive Compounds and Antitumor Agents