Lipid Transport by <i>Candida albicans</i> Dnf2 Is Required for Hyphal Growth and Virulence
Bhawik K. Jain, Andrew S. Wagner, Todd B. Reynolds, Todd R. Graham
Abstract
Candida albicans is a common cause of human mucosal yeast infections, and invasive candidiasis can be fatal. Antifungal medications are limited, but those targeting the pathogen cell wall or plasma membrane have been effective.
Topics & Concepts
BiologyCandida albicansVirulenceESCRTATP-binding cassette transporterCorpus albicansFlippaseAntifungal drugSaccharomyces cerevisiaeCell biologyMicrobiologyBiochemistryYeastIntracellularTransporterMembraneEndosomePhosphatidylserineGenePhospholipidAntifungal resistance and susceptibilityFungal Infections and StudiesAntibiotic Resistance in Bacteria