A <i>Λ</i>-Ir(<scp>iii</scp>)-phenylquinazolinone complex enhances ferroptosis by selectively inhibiting metallothionein-1
Lu Zhu, Xingyun Wang, Xingyun Wang, Tian Tian, Yanyan Chen, Wenjing Du, Wei Wei, Jing Zhao, Zijian Guo, Xiuxiu Wang, Xiuxiu Wang
Abstract
-IrPPQ achieved precise regulation of ferroptosis in pancreatic cancer cells. This work provides new insights into the design of chiral ferroptosis-inducing metallodrugs for future pancreatic cancer therapy.
Topics & Concepts
MetallothioneinChemistryCell biologyCancer cellCancerBiochemistryBiologyGeneGeneticsFerroptosis and cancer prognosisDrug Transport and Resistance MechanismsRNA modifications and cancer