Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation
Niels Harlaar, Sven O. Dekker, Juan Zhang, Rebecca R. Snabel, Marieke W. Veldkamp, Arie O. Verkerk, Carla Cofiño Fabres, Verena Schwach, Lente J. S. Lerink, Mathilde R. Rivaud, Aat A. Mulder, Willem E. Corver, Marie José T. H. Goumans, Dobromir Dobrev, Robert J. M. Klautz, Martin J. Schalij, Gert Jan C. Veenstra, Robert Passier, Thomas J. van Brakel, Daniël A. Pijnappels, Antoine A. F. de Vries
Topics & Concepts
Atrial myocytesIn vitroAtrial fibrillationMyocyteCell cultureImmortalised cell lineCellular modelElectrophysiologyIn vivoCellCell biologyHEK 293 cellsRecombinant DNAInternal medicineCardiologyMedicineBiologyAtrium (architecture)FibrillationCell typeAtrial action potentialCell physiologyIn vitro toxicologyChemistryMonoclonal antibodyCell growthReentryViral vectorReceptorCancer researchCellular differentiationAtrial Fibrillation Management and OutcomesMesenchymal stem cell researchPluripotent Stem Cells Research