Phosphoproteomics identify arachidonic-acid-regulated signal transduction pathways modulating macrophage functions with implications for ovarian cancer
Raimund Dietze, Mohamad K. Hammoud, María Gómez‐Serrano, Annika Unger, Tim Bieringer, Florian Finkernagel, Anna M. Sokòl, Andrea Nist, Thorsten Stiewe, Silke Reinartz, Viviane Ponath, Christian Preußer, Elke Pogge von Strandmann, Sabine Müller‐Brüsselbach, Johannes Graumann, Rolf Müller
Abstract
Our results suggest that AA contributes to an unfavorable clinical outcome of OC by impacting the phenotype of tumor-associated macrophages. Besides critical AA-regulated signal transduction proteins identified in the present study, PLA2G2A might represent a potential prognostic tool and therapeutic target to interfere with OC progression.
Topics & Concepts
PhosphoproteomicsCell biologySignal transductionBiologyPhosphorylationTyrosine phosphorylationArachidonic acidProtein kinase ABiochemistryProtein phosphorylationEnzymeExtracellular vesicles in diseaseMicroRNA in disease regulationImmune cells in cancer