Post-translational down-regulation of Nrf2 and YAP proteins, by targeting deubiquitinases, reduces growth and chemoresistance in pancreatic cancer cells
Margherita Grattarola, Marie Angèle Cucci, Antonella Roetto, Chiara Dianzani, Giuseppina Barrera, Stefania Pizzimenti
Topics & Concepts
Downregulation and upregulationCycloheximidePancreatic cancerCancer researchCancer cellCell cultureCell biologyOxidative stressChemistryBiologyProtein biosynthesisCancerMolecular biologyBiochemistryGeneGeneticsUbiquitin and proteasome pathwaysHippo pathway signaling and YAP/TAZCancer-related gene regulation