Natural Products Originated from the Oxidative Coupling of Tyrosine and Tryptophan: Biosynthesis and Bioinspired Synthesis
Shanyu Tang, Guillaume Vincent
Abstract
The oxidative coupling of tyrosine and tryptophan units is a pivotal step in the total synthesis of some peptide-derived marine and terrestrial natural products, such as the diazonamides, azonazine and tryptorubin A. This Minireview details the biosynthesis and bioinspired synthesis of natural products with such structures. A special focus is put on the challenges of the synthesis of these natural products and the innovative solutions adopted by synthetic chemists.
Topics & Concepts
TyrosineBiosynthesisTryptophanOxidative coupling of methaneOxidative phosphorylationChemistryBiochemistryTotal synthesisNatural (archaeology)Combinatorial chemistryBiologyStereochemistryAmino acidCatalysisEnzymePaleontologyMicrobial Natural Products and BiosynthesisMarine Sponges and Natural ProductsSynthesis and Biological Activity