Plasma extracellular vesicles from recurrent GBMs carrying LDHA to activate glioblastoma stemness by enhancing glycolysis
Xin Zhang, Junjie Li, Yiyao Huang, Anming Yang, Xiaoliu Liu, Yunhao Luo, Hao Tian, Minghui Wen, Chengzong Zhong, Peng Bin, Haitao Sun, Lei Zheng
Abstract
Our study highlights LDHA-loaded EVs as key mediators promoting GSC properties and metabolic reprogramming in GBM. These findings provide insights into recurrence mechanisms and suggest potential liquid biopsy approaches for monitoring and preventing GBM relapse.
Topics & Concepts
Extracellular vesiclesGlioblastomaGlycolysisExtracellularCell biologyChemistryCancer researchVesicleBiologyBiochemistryMetabolismMembraneExtracellular vesicles in diseaseNanoplatforms for cancer theranosticsMXene and MAX Phase Materials