Tunable enzymatically degradable hydrogels for controlled cargo release with dynamic mechanical properties
Riho Tanimoto, Mitsuhiro Ebara, Koichiro Uto
Abstract
' decreased by enzyme addition, and the degradation rate decreased with the initial crosslinking density of the hydrogel. The degradation rate could also be controlled with the reactivity of peptide sequences against collagenase. With these findings, the retention and release of FITC-dextran were successfully controlled by tuning the mesh size and degradability of the hydrogel. This report provides useful insights for designing hydrogels as cell scaffolds or functional molecular delivery matrices with tunable dynamic mechanical properties and the resulting release of loaded drugs or proteins.
Topics & Concepts
Self-healing hydrogelsPEG ratioEthylene glycolDynamic mechanical analysisCollagenaseMaterials scienceDextranChemical engineeringDegradation (telecommunications)Polymer chemistryChemistryComposite materialPolymerEnzymeOrganic chemistryEngineeringEconomicsTelecommunicationsFinanceComputer scienceHydrogels: synthesis, properties, applicationsPolymer Surface Interaction Studies3D Printing in Biomedical Research