Loss of Neutrophil Homing to the Periodontal Tissues Modulates the Composition and Disease Potential of the Oral Microbiota
A. Hashim, A. Alsam, M. A. Payne, J. Aduse-Opoku, M. A. Curtis, S. Joseph
Abstract
Periodontal disease is considered to arise from an imbalance in the interplay between the host and its commensal microbiota, characterized by inflammation, destructive periodontal bone loss, and a dysbiotic oral microbial community. The neutrophil is a key component of defense of the periodontium: defects in their number or efficacy of function predisposes individuals to development of periodontal disease.
Topics & Concepts
MicrobiomeBiologyOral MicrobiomeImmunologyHoming (biology)DysbiosisPeriodontal diseaseInflammationDiseasePeriodontal pathogenFusobacteriaMicrobiologyPhenotypeLeukocyte adhesion deficiencyPeriodontitisGingival and periodontal pocketOral microbiologyFusobacteriumGingivitisPathogenGranulocyteImmune systemHuman microbiomeInnate immune systemNeutrophil extracellular trapsTooth lossDental plaqueBacteroidaceaeImmunityInfiltration (HVAC)Oral microbiology and periodontitis researchPeriodontal Regeneration and TreatmentsOral and gingival health research