Compartmentalized regulation of NAD+ by Di (2-ethyl-hexyl) phthalate induces DNA damage in placental trophoblast
Shuai Zhao, Yun Soo Hong, Yue-yue Liang, Xiaolu Li, Jiang-chuan Shen, Congcong Sun, Lingluo Chu, Jie Hu, Hua Wang, De‐Xiang Xu, Shichen Zhang, Doudou Xu, Tao Xu, Lingli Zhao
Abstract
precursor NAM can partially rescue the DNA and mitochondria damage. It provides a new idea for the prevention of health problems of offsprings caused by DEHP injury to the placenta.
Topics & Concepts
NAD+ kinasePARP1DNA damageMitochondrial DNAMitochondrionDNA repairPhthalateDNATrophoblastBiologyChemistryBiochemistryCell biologyPlacentaPoly ADP ribose polymeraseEnzymeGeneticsGeneFetusPregnancyPolymeraseOrganic chemistryAnesthesia and Neurotoxicity ResearchEpigenetics and DNA MethylationBirth, Development, and Health