Increased Accumulation of Squalene in Engineered Yarrowia lipolytica through Deletion of <i>PEX10</i> and <i>URE2</i>
Liujing Wei, Xuan Cao, Jing‐Jing Liu, Suryang Kwak, Yong‐Su Jin, Wei Wang, Qiang Hua
Abstract
This study demonstrated a novel strategy for increasing squalene production in Y. lipolytica . URE2, a bifunctional protein that is involved in both nitrogen catabolite repression and oxidative stress response, was identified and demonstrated correlation to squalene production.
Topics & Concepts
YarrowiaSqualeneBiochemistryYeastBiologyCatabolite repressionSaccharomyces cerevisiaeChemistryGeneMutantMicrobial Metabolic Engineering and BioproductionPlant biochemistry and biosynthesisLipid metabolism and biosynthesis