Structure of the human GlcNAc-1-phosphotransferase αβ subunits reveals regulatory mechanism for lysosomal enzyme glycan phosphorylation
Hua Li, Wang‐Sik Lee, Xiang Feng, Lin Bai, Benjamin C. Jennings, Lin Liu, Balraj Doray, William M. Canfield, Stuart Kornfeld, Huilin Li, Huilin Li, Huilin Li
Topics & Concepts
GlycanPhosphorylationBiochemistryPhosphotransferaseEnzymeMannoseHydrolaseActive siteChemistryProtein subunitGlycosylationEnzyme activatorBinding siteLysosomeCell biologyBiologyGlycoproteinGeneLysosomal Storage Disorders ResearchGlycosylation and Glycoproteins ResearchCellular transport and secretion