Electrochemical Synthesis of Cyclic Diaryl Phosphinamides via Intramolecular sp<sup>2</sup> C–H Phosphinamidation
Wenchao Gao, Luyi Zong, Weilong Wu, Ming Zhu, Wenmin Liu, Yiyang Zhao, Ting Li, Sheng Zhang
Abstract
We developed an oxidant- and transition-metal-free approach to construct six-membered cyclic phosphinamides via an intramolecular electrochemical C–H phosphinamidation process. With nBu4NBr as the catalyst and electrolyte, cyclic phosphinamides bearing a variety of functional groups (22 examples) were readily accessed under mild conditions. Meanwhile, this protocol provided an alternative route to organic electroluminescent materials and P–N ligands.
Topics & Concepts
Intramolecular forceElectrochemistryChemistryCatalysisSupporting electrolyteElectroluminescenceTransition metalCombinatorial chemistryStereochemistryElectrodeOrganic chemistryPhysical chemistryLayer (electronics)Sulfur-Based Synthesis TechniquesRadical Photochemical ReactionsCatalytic C–H Functionalization Methods