Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function
Frederike A. Hartl, Esmeralda Beck-Garcìa, Nadine M. Woessner, Lea J. Flachsmann, Rubí M.-H. Velasco Cárdenas, Simon M. Brandl, Sanaz Taromi, Gina J. Fiala, Anna Morath, Pankaj Mishra, O. Sascha Yousefi, Julia Zimmermann, Nico Hoefflin, Maja Köhn, Birgitta M. Wöhrl, Robert Zeiser, Kristian Schweimer, Stefan Günther, Wolfgang W. Schamel, Susana Minguet
Topics & Concepts
T-cell receptorCD3Cell biologyChimeric antigen receptorImmunoreceptor tyrosine-based activation motifTyrosine kinasePhosphorylationSignal transductionBiologyT cellJurkat cellsCancer researchChemistryAntigenSH2 domainImmunologyCD8Immune systemCAR-T cell therapy researchMonoclonal and Polyclonal Antibodies ResearchChronic Lymphocytic Leukemia Research