Cyaonoside A-loaded composite hydrogel microspheres to treat osteoarthritis by relieving chondrocyte inflammation
Xingyan An, Fengjin Zhou, Guangfeng Li, Yan Wei, Biaotong Huang, Mengmeng Li, Qin Zhang, Ke Xu, Robert Chunhua Zhao, Jiacan Su
Abstract
. In the osteoarthritis mouse model, HLC demonstrated promising therapeutic capabilities by protecting the integrity of articular cartilage. In conclusion, this study provides insights into the regulatory mechanisms of CyA for chondrocytes and proposes a composite hydrogel microsphere-based advanced therapeutic strategy for osteoarthritis.
Topics & Concepts
MicrosphereOsteoarthritisChondrocyteMaterials scienceComposite numberBiomedical engineeringMedicineComposite materialCartilageChemical engineeringPathologyAnatomyEngineeringAlternative medicineOsteoarthritis Treatment and MechanismsProteoglycans and glycosaminoglycans researchAdvanced Drug Delivery Systems