Deletion of Nrf2 shortens lifespan in C57BL6/J male mice but does not alter the health and survival benefits of caloric restriction
Laura C.D. Pomatto, Theresa Dill, Lindsey Carboneau, Sophia Levan, Jonathan Kato, Evi M. Mercken, Kevin Pearson, Michel Bernier, Rafael de Cabo
Topics & Concepts
Downregulation and upregulationCaloric theoryKnockout mouseBiologyCalorie restrictionActivator (genetics)Restricted dietOxidative stressLongevityEndocrinologyCell biologyGerontologyGeneticsMedicineGeneGenetics, Aging, and Longevity in Model OrganismsGenomics, phytochemicals, and oxidative stressAdipose Tissue and Metabolism