Pyrimidine-directed metal-free C–H borylation of 2-pyrimidylanilines: a useful process for tetra-coordinated triarylborane synthesis
Supriya Rej, Amrita Das, Naoto Chatani
Abstract
-C-H borylation of 2-pyrimidylaniline derivatives. The approach allowed us to synthesize various boronates, which are synthetically important compounds and various four-coordinated triarylborane derivatives, which could be useful in materials science as well as Lewis-acid catalysts. This metal-free directed C-H borylation reaction proceeds smoothly without any interference by external impurities, such as inorganic salts, reactive functionalities, heterocycles and even transition metal precursors, which further enhance its importance.
Topics & Concepts
BorylationTetraChemistryPyrimidineLewis acids and basesCombinatorial chemistryMetalCatalysisBoronic acidOrganic chemistryMedicinal chemistryStereochemistryArylAlkylOrganoboron and organosilicon chemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions