Reactivities of cyclam derivatives with metal–amyloid-β
Gun‐Hee Kim, Evan Lelong, Juhye Kang, Jong‐Min Suh, Nathalie Le Bris, Hélène Bernard, Dongwook Kim, Raphaël Tripier, Mi Hee Lim
Abstract
New examples of azamacrocyclic metal chelators that modulate the interactions between metal ions and Aβ and the reactivities of metal–Aβ were developed under criteria based on structural and functional variations on the backbone of<bold>Cyclam</bold>.
Topics & Concepts
CyclamMetalMetal ions in aqueous solutionChemistryOrganic chemistryMetal complexes synthesis and propertiesMolecular Sensors and Ion DetectionComputational Drug Discovery Methods