Trimethylamine N-oxide promotes oxidative stress and lipid accumulation in macrophage foam cells via the Nrf2/ABCA1 pathway
Zhisheng Luo, Xiaochen Yu, Chao Wang, Haiyan Zhao, Xinming Wang, Xiuru Guan
Topics & Concepts
Oxidative stressABCA1Foam cellChemistryReactive oxygen speciesDownregulation and upregulationGlutathioneCell biologyTrimethylamine N-oxideAntioxidantLipid metabolismSuperoxide dismutaseLipid oxidationABCG1BiochemistryCholesterolLipoproteinTrimethylamineBiologyEnzymeTransporterGeneGenomics, phytochemicals, and oxidative stressIL-33, ST2, and ILC PathwaysEicosanoids and Hypertension Pharmacology