β2-adrenergic Agonists Rescue Lysosome Acidification and Function in PSEN1 Deficiency by Reversing Defective ER-to-lysosome Delivery of ClC-7
Ju‐Hyun Lee, Devin M. Wolfe, Sandipkumar Darji, Mary Kate McBrayer, Daniel J. Colacurcio, Asok Kumar, Philip Stavrides, Panaiyur S. Mohan, Ralph A. Nixon
Topics & Concepts
LysosomeAutophagyPSEN1Endoplasmic reticulumCell biologyChemistryHomeostasisEndocytic cyclePresenilinBiologyInternal medicineBiochemistryMedicineReceptorAlzheimer's diseaseEndocytosisEnzymeApoptosisDiseaseAutophagy in Disease and TherapyCalcium signaling and nucleotide metabolismCellular transport and secretion