Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses
Jie Chen, Shane M. Harding, Ramakrishnan Natesan, Lei Tian, Joseph L. Benci, Weihua Li, Andy J. Minn, Irfan A. Asangani, Roger A. Greenberg
Abstract
checkpoint. These findings link aberrant cell progression and p53 loss to an expanded spectrum of damage-associated molecular pattern recognition and have implications for the design of rational approaches to augment anti-tumor immune responses.
Topics & Concepts
MitosisBiologyDNA damageG2-M DNA damage checkpointCell biologyCell cycleImmune systemCell cycle checkpointCancer researchPattern recognition receptorCyclin-dependent kinase 1CellDNAImmunologyInnate immune systemGeneticsinterferon and immune responsesImmune cells in cancerRNA modifications and cancer