MarR-Dependent Transcriptional Regulation of <i>mmpSL5</i> Induces Ethionamide Resistance in Mycobacterium abscessus
Ronald Rodriguez, Nick Campbell-Kruger, Jesus Gonzalez Camba, John C. Berude, Rachel Fetterman, Sarah A. Stanley
Abstract
Mycobacterium abscessus ( Mabs ) is an emerging nontuberculosis mycobacterial (NTM) pathogen responsible for a wide variety of respiratory and cutaneous infections that are difficult to treat with standard antibacterial therapy. Mabs has a high degree of both innate and acquired antibiotic resistance to most clinically relevant drugs, including standard anti-mycobacterial agents. Ethionamide (ETH), an inhibitor of mycolic acid biosynthesis, is currently utilized as a second-line agent for treating multidrug-resistant tuberculosis infections.
Topics & Concepts
EthionamideMycobacterium abscessusMicrobiologyMycobacteriumMycobacterium tuberculosisBiologyMedicineGeneticsAntibioticsBacteriaTuberculosisEthambutolStreptomycinPathologyMycobacterium research and diagnosisTuberculosis Research and EpidemiologyQuinazolinone synthesis and applications