Role of epithelial cell-mesenchymal transition regulators in molecular typing and prognosis of colon cancer
Shengquan He, Xiaowen Li, Xindong Zhou, Weiming Weng, Jiajun Lai
Abstract
Background: Despite advances in colon cancer screening, diagnosis, chemotherapy, and targeted therapy, the prognosis remains poor once colon cancer develops distant metastasis or local recurrence. To further improve the prognosis of colon cancer patients, researchers or clinicians may need to identify new indicators for predicting the prognosis and treatment of colon cancer. Methods: In order to discover the new mechanism of epithelial-mesenchymal transition (EMT) promoting tumor progression and to find new indicators of colon cancer diagnosis, targeted therapy and prognosis, this study conducted The Cancer Genome Atlas (TCGA) analysis, differential gene analysis, prognostic analysis, protein-protein interaction (PPI), enrichment analysis, molecular typing, and a machine algorithm were combined with data from TCGA and Gene Expression Omnibus (GEO) databases and EMT-related genes. Results: genes were characteristic genes for clinical prognosis of colon cancer. Conclusions: may have good application potential. The findings provide a theoretical basis for the next clinical transformation in the treatment of colon cancer.