Antigenic Landscape Analysis of Individuals Vaccinated with a Universal Influenza Virus Vaccine Candidate Reveals Induction of Cross-Subtype Immunity
Philip Meade, Shirin Strohmeier, Maria C. Bermúdez‐González, Adolfo García‐Sastre, Peter Palese, Viviana Simon, Florian Krammer
Abstract
The development of a universal influenza virus vaccine that protects against seasonal drifted, zoonotic, or emerging pandemic influenza viruses would be an extremely useful public health tool. Here, we test a technology designed to measure the breadth of antibody responses induced by this new class of vaccines.
Topics & Concepts
VirologyBiologyAntigenic driftHemagglutinin (influenza)VirusOriginal antigenic sinInfluenza A virusH5N1 genetic structureVaccinationInfluenza vaccineAntigenic shiftImmunityImmune systemImmunologyMedicineInfectious disease (medical specialty)Coronavirus disease 2019 (COVID-19)DiseasePathologyInfluenza Virus Research StudiesRespiratory viral infections researchMonoclonal and Polyclonal Antibodies Research