Artesunate promotes the proliferation of neural stem/progenitor cells and alleviates Ischemia-reperfusion Injury through PI3K/Akt/FOXO-3a/p27kip1 signaling pathway
Kaiyuan Zhang, Yang Yang, Hongfei Ge, Ju Wang, Xuezhu Chen, Xuejiao Lei, Jun Zhong, Chao Zhang, Jishu Xian, Yongling Lu, Liang Tan, Hua Feng
Abstract
and enhancing neural stem cell proliferation in the infarcted cortex via PI3K/AKT signaling, further alleviating ischemia-reperfusion injury after ischemic stroke.
Topics & Concepts
Subventricular zoneNeural stem cellPI3K/AKT/mTOR pathwayProtein kinase BWortmanninProgenitor cellNeurogenesisStem cellCell biologyNestinReperfusion injuryIschemiaCancer researchMedicinePharmacologyBiologySignal transductionChemistryInternal medicineMicroRNA in disease regulationNeurogenesis and neuroplasticity mechanismsFOXO transcription factor regulation