Evolving Approaches for Pharmacological Therapy of Obesity
Ariana M. Chao, Simeon I. Taylor, Molly Moore, Anastassia Amaro, Thomas A. Wadden
Abstract
Obesity is a global health concern. Progress in understanding the physiology of obesity and weight reduction has provided new drug targets. Development and testing of new antiobesity medications (AOMs) has the potential to quickly expand options for treatment. In this review, we briefly summarize the physiology of obesity and weight reduction, as well as medications currently approved for weight management. We highlight the increasing use of incretin and nutrient-stimulated hormone-based therapies. We conclude with an overview of AOMs progressing through the pipeline and discuss their implications for the rapidly evolving field of obesity management.
Topics & Concepts
ObesityWeight lossMedicineIntensive care medicineBioinformaticsIncretinWeight managementBiologyDiabetes mellitusInternal medicineEndocrinologyType 2 diabetesPharmacology and Obesity TreatmentRegulation of Appetite and ObesityDiet and metabolism studies