Cytomegalovirus-specific neutralizing antibodies effectively prevent uncontrolled infection after allogeneic hematopoietic stem cell transplantation
Huiru Wang, Huilan Liu, Zhou Li, Dongyao Wang, Shushu Wang, Qian Liu, Yun Wu, Mei‐Juan Tu, Zimin Sun, Xiaohu Zheng, Binqing Fu, Baolong Wang, Haiming Wei
Abstract
because of its lower content of anti-CMV-specific immunoglobulin G (IgG) than the controlled infection group. Overall, these results highlighted the contribution of B cells and anti-CMV-specific neutralizing IgGs to the restraint of CMV infection post-allo-HSCT, suggesting their potential as a supplementary treatment to improve outcomes.
Topics & Concepts
Hematopoietic stem cell transplantationCytomegalovirusImmunologyAntibodyStem cellTransplantationImmune systemCXCR4HaematopoiesisGroup BGroup AB cellVirologyNeutralizing antibodyCytomegalovirus infectionBiologyMedicineVirusHuman cytomegalovirusHerpesviridaeViral diseaseInternal medicineChemokineGeneticsCytomegalovirus and herpesvirus researchImmune Cell Function and InteractionHerpesvirus Infections and Treatments