Endothelial ZIP8 plays a minor role in BMP6 regulation by iron in mice
Allison L. Fisher, Sydney Phillips, Chia‐Yu Wang, João A. Paulo, Xia Xiao, Gillian A. Moschetta, Adhvaith Sridhar, Joseph D. Mancias, Jodie L. Babitt
Abstract
ABSTRACT: Iron-mediated induction of bone morphogenetic protein (BMP)6 expression by liver endothelial cells is essential for iron homeostasis regulation. We used multiple dietary and genetic mouse cohorts to demonstrate a minor functional role for the metal-ion transporter ZIP8 in regulating BMP6 expression under high-iron conditions.
Topics & Concepts
MedicineInternal medicineIron Metabolism and DisordersTrace Elements in HealthHemoglobinopathies and Related Disorders