Common Biosynthesis of Non‐Canonical C <sub>16</sub> Terpenes through a Fragmentation‐Recombination Mechanism
Houchao Xu, Bernd Goldfuß, Jeroen S. Dickschat
Abstract
sesquiterpenoids named after ancient Greek philosophers, archimedene, aristotelene, eratosthenene, pythagorene, α-democritene and anaximandrene, was investigated through density functional theory (DFT) calculations and isotopic labeling experiments. The results revealed for all compounds except archimedene a unique fragmentation-recombination mechanism as previously demonstrated for sodorifen biosynthesis, in addition to a remarkable "dancing" mechanism for anaximandrene biosynthesis.
Topics & Concepts
Fragmentation (computing)TerpeneRecombinationBiosynthesisChemistryMechanism (biology)StereochemistryBiologyPhysicsBiochemistryEcologyGeneQuantum mechanicsPlant biochemistry and biosynthesisMicrobial Natural Products and BiosynthesisNatural product bioactivities and synthesis