Transorgan short-chain fatty acid fluxes in the fasted and postprandial state in the pig
Sarah K. Kirschner, Gabriëlla A. M. Ten Have, M.P. Engelen, Nicolaas E.P. Deutz
Abstract
Using a multicatheterized pig model, we identified the portal-drained viscera as the main releasing compartment of the short-chain fatty acids acetate, propionate, butyrate, isovalerate, and valerate in the fasted and postprandial states. Low hepatic acetate metabolism resulted in a high splanchnic release, whereas all other SCFAs were extensively cleared resulting in low but significant splanchnic releases. Muscle and kidneys are the main peripheral SCFA metabolizing organs during fasting and in the postprandial state.
Topics & Concepts
PostprandialValerateButyratePropionateIsovalerateSplanchnicClearanceEndocrinologyInternal medicineChemistryFatty acidMetabolismBiochemistryBiologyMedicineInsulinBlood flowFermentationUrologyDiet and metabolism studiesAnimal Nutrition and PhysiologyMeat and Animal Product Quality